Journal: Acta Pharmaceutica Sinica. B

Article Title: Recent advances in nanomedicines for the treatment of ischemic stroke

doi: 10.1016/j.apsb.2020.11.019

Figure Lengend Snippet: Ligands corresponding to receptors and their applications in targeted delivery of nanomedicines.

Article Snippet: , Biomimetic targeting , miR-124-loaded exosomes modified with rabies virus glycoprotein which could bind the nAChR on BBB , Promoted neural precursor cells in the infarcted area to differentiate into neurons , Neuron-specific targeting ability needs further improvement , .

Techniques: Modification, Membrane, Liposomes, Virus

Journal: Acta Pharmaceutica Sinica. B

Article Title: Recent advances in nanomedicines for the treatment of ischemic stroke

doi: 10.1016/j.apsb.2020.11.019

Figure Lengend Snippet: The strategies, including achievements and limitations in targeted delivery of nanomedicines in reducing oxidative stress.

Article Snippet: , Biomimetic targeting , miR-124-loaded exosomes modified with rabies virus glycoprotein which could bind the nAChR on BBB , Promoted neural precursor cells in the infarcted area to differentiate into neurons , Neuron-specific targeting ability needs further improvement , .

Techniques: In Vivo, Modification, Expressing, Liposomes, Injection

Journal: Acta Pharmaceutica Sinica. B

Article Title: Recent advances in nanomedicines for the treatment of ischemic stroke

doi: 10.1016/j.apsb.2020.11.019

Figure Lengend Snippet: The strategies, including achievements and limitations in targeted delivery of nanomedicines in reducing apoptosis.

Article Snippet: , Biomimetic targeting , miR-124-loaded exosomes modified with rabies virus glycoprotein which could bind the nAChR on BBB , Promoted neural precursor cells in the infarcted area to differentiate into neurons , Neuron-specific targeting ability needs further improvement , .

Techniques: Liposomes, Modification, Derivative Assay

Journal: Acta Pharmaceutica Sinica. B

Article Title: Recent advances in nanomedicines for the treatment of ischemic stroke

doi: 10.1016/j.apsb.2020.11.019

Figure Lengend Snippet: The strategies, including achievements and limitations in targeted delivery of nanomedicines which could regulate inflammation response and promote tissue repair.

Article Snippet: , Biomimetic targeting , miR-124-loaded exosomes modified with rabies virus glycoprotein which could bind the nAChR on BBB , Promoted neural precursor cells in the infarcted area to differentiate into neurons , Neuron-specific targeting ability needs further improvement , .

Techniques: Liposomes, In Vivo, Modification, Activity Assay, Virus, Derivative Assay, Functional Assay

Journal: Pharmaceutics

Article Title: Recent Advances in Lipid Nanoparticles for Delivery of mRNA

doi: 10.3390/pharmaceutics14122682

Figure Lengend Snippet: Current clinical trials of LNP@mRNA.

Article Snippet: CureVac , CV7202 , Rabies , Rabies virus glycoprotein (RABV-G) , i.m. , LNP , NCT03713086 (I).

Techniques: Clinical Proteomics, Plasmid Preparation, Infection, Virus, Membrane, Injection

Journal: Chemical reviews

Article Title: Lipids and Lipid Derivatives for RNA Delivery

doi: 10.1021/acs.chemrev.1c00244

Figure Lengend Snippet: Representative Clinical Trials of Lipid-Based RNA Therapies

Article Snippet: CV7202 , Rabies , mRNA encoding Rabies virus G glycoprotein , LNP , IM , CureVac , I , NCT03713086.

Techniques: Infection, Isolation, CRISPR

Journal: Vaccines

Article Title: Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans

doi: 10.3390/vaccines9010061

Figure Lengend Snippet: Proposed sequence of events leading to the generation of adaptive immune responses upon mRNA vaccination. Local inflammation at the injection site promotes the infiltration of immune cells, including neutrophils, monocytes, myeloid dendritic cells (MDCs) and plasmacytoid dendritic cells (PDCs). Neutrophils can efficiently take up LNPs, but monocytes and MDCs translate mRNA more efficiently. Secretion of type I interferons (IFNs) is stimulated. mRNA/LNP and protein antigen will disseminate and cells will migrate to the vaccine-draining lymph nodes. Antigen presentation to T cells and interactions of antigen and B cells take place at these sites. This leads to the formation of germinal centers, which results in the generation of memory B cells and antibody-producing plasma cells that reside to the bone marrow. The basic illustration was made by Elizabeth Thompson and some elements were created using BioRender.com .

Article Snippet: One of the early-generation mRNA vaccines that has been extensively studied was developed by one of the largest mRNA vaccine companies, CureVac AG (Tübingen, Germany), and was based on sequence-optimized, chemically unmodified mRNA encoding the rabies virus glycoprotein (RABV-G).

Techniques: Sequencing, Injection

Journal: Scientific Reports

Article Title: A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency

doi: 10.1038/s41598-017-07687-7

Figure Lengend Snippet: Graphical comparisons of the present TRFIA and ELISA results for assay of rabies virus glycoprotein.

Article Snippet: The Rabies Virus Glycoprotein ELISA Kit (EIA-2489) was procured from DRG Instruments GmbH (Marburg, Germany).

Techniques: Enzyme-linked Immunosorbent Assay, Virus

Journal: Scientific Reports

Article Title: A time-resolved fluoroimmunoassay to assay the rabies virus glycoprotein: application for estimation of human rabies vaccine potency

doi: 10.1038/s41598-017-07687-7

Figure Lengend Snippet: Comparison of assay performance for the present TRFIA and ELISA.

Article Snippet: The Rabies Virus Glycoprotein ELISA Kit (EIA-2489) was procured from DRG Instruments GmbH (Marburg, Germany).

Techniques: Comparison, Enzyme-linked Immunosorbent Assay